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GLP-1s containing tirzepatide may reduce the risk of major heart problems like stroke by 30% in people with obesity whove undergone a heart procedure known as a transcatheter aortic valve replacement (TAVR)

For a lot of people, 80 to 90 grams a day feels like a sweet spot, enough to feel good without pushing past your limits

Levothyroxine adjustment can be needed after significant weight loss

It binds GLP-1 receptors for appetite suppression and glucose control, GIP receptors for enhanced insulin sensitivity and fat metabolism, and glucagon receptors for direct energy expenditure and thermogenesis

But over time, excess liver fat can lead to inflammation and scarring (known as fibrosis), which in some cases may progress to cirrhosis